منابع مشابه
Distribution of Sulfonamide Compounds
overcome. Sulfanilamide, sulfathiazole, sulfadiazene, and sulfapyridine were measured by the method of Bratton and Marshall (2), using a photoelectric colorimeter.2 Substrates and ultrafiltrates of serum were obtained according to Lavietes' method (3). It had been established previously that contact with mercury did not affect the determination of sulfonamide compounds in serum. The effects of ...
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Density Functional Theory (DFT) calculations at the B3LYP/6-31+G∗ level have been performed on 5-thiabicyclo[2.1.1]hex-2-ene S-oxide derivatives. The geometrical and electronic properties of the compounds have been analyzed in order to explain the favored stability of the exo configuration. Isodesmic reactions at the Gaussian-G2 theory yielded the exo conformer as the most stable one. Moreover,...
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Despite the urgent need for effective antimalarial drugs with novel modes of action no new chemical class of antimalarial drug has been approved for use since 1996. To address this, we have used a rational approach to investigate compounds comprising the primary benzene sulfonamide fragment as a potential new antimalarial chemotype. We report the in vitro activity against Plasmodium falciparum ...
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The first examples of the directed, boron-mediated aldol reaction between different ketones are presented. Transformation of a variety of ketones to their corresponding boron enolates with Chx2BCl/Et3N, followed by reaction with acceptor ketones in diethyl ether, and oxidation of the resultant boron aldolate (H2O2, MeOH/pH 7 buffer), provided the aldol addition products. The reaction was most f...
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A feature of sulfonamide therapy for bacterial infections is that species of bacteria differ in their resistance to the antibacterial action of the compounds. It is also recognized that strains of microorganisms within the same species display variations in susceptibility. A disconcerting and confusing factor associated with chemotherapy, which appears to be assuming increasing clinical signifi...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2017
ISSN: 1948-5875,1948-5875
DOI: 10.1021/acsmedchemlett.7b00049